2020 Aug;43(4):515-538. doi: 10.1007/s13402-020-00513-9. Natl. ACS Nano 3, 29192926. Hydroponic Ginseng ROOT Mediated with CMC Polymer-Coated Zinc Oxide Nanoparticles for Cellular Apoptosis via Downregulation of. Transl. Research Immunological aspects of cancer chemotherapy. Nanotechnology has been extensively studied and exploited for cancer treatment as nanoparticles can play a significant role as a drug delivery system. In this process, NPs, such as PLGA-PEG (Tang X. et al., 2020) and PEGylated and non-PEGylated liposomes (Iwase and Maitani, 2012), can offer better platforms to achieve combination therapy. Cancer Res. Cancer nanotechnology: application of nanotechnology in cancer therapy. However, limitations such as lack of specificity, cytotoxicity, and multi-drug resistance pose a substantial challenge for favorable cancer treatment. Specialization of tumour vasculature. doi: 10.1016/j.colsurfb.2018.12.038, Liu, L., Wei, Y., Zhai, S., Chen, Q., and Xing, D. (2015). 13, 256262. (2018) utilized an amphiphilic cationic NP complex encapsulating paclitaxel and the Bcl-2 convertor gene in order to inhibit drug-resistant liver cancer cell growth. The . doi: 10.2174/1389450117666160602202339. Thus, the folate receptor-targeting strategy by folate-conjugated nanomaterials has been widely used for cancer treatments (Muralidharan et al., 2016; Samadian et al., 2016). Nanotechnology has the ability to improve catalysis and that is helping at improving fuel production efficiency. doi: 10.1007/bf02828142, Xiao, Q., Zhu, X., Yuan, Y., Yin, L., and He, W. (2018). Lett. (2019). (2010). NPs with a diameter range of 10 to 100 nm are generally considered suitable for cancer therapy, as they can effectively deliver drugs and achieve enhanced permeability and retention (EPR) effect. Rev. Therefore, a situational approach should be used when assessing the benefits and drawbacks to using 98, 764771. J. Huazhong Univ. Here, the authors design a series of nanogels with distinctive stiffness and investigate how nanogel mechanical properties could be leveraged to overcome RES. Toy R, Bauer L, Hoimes C, Ghaghada KB, Karathanasis E. Adv Drug Deliv Rev. Here we use a bottlebrush prodrug platform to show that the delivery of three drugs in a synergistic combination in animal models outperforms other combinatorial approaches for multiple myeloma therapy. This work is a pioneer study that was able to successfully overcome both pump- and non-pump-mediated drug resistance. Res. Biol. 68, 545554. Gonzalez-Angulo AM, Morales-Vasquez F, Hortobagyi GN. Front Immunol. COX-2 contributes to P-glycoprotein-mediated multidrug resistance via phosphorylation of c-Jun at Ser63/73 in colorectal cancer. (2018). doi: 10.2217/nnm.11.93, Nicholson, R. I., Gee, J. M., and Harper, M. E. (2001). Litman, T., Brangi, M., Hudson, E., Fetsch, P., Abati, A., Ross, D. D., et al. In addition, heat shock protein 90 (HSP90) is required for HIF-1 transcriptional activity, and inhibition of HSP90 can also down-regulate HIF-1 expression (Semenza, 2007). Nanotechnology based imaging contrast agents being developed and translated today, offer the ability to specifically target and greatly enhance detection of tumor in vivo by way of conventional scanning devices, such as magnetic resonance imaging (MRI), (PET), and computed tomography (CT). doi: 10.1016/j.ejpb.2016.12.019, Carita, A. C., Eloy, J. O., Chorilli, M., Lee, R. J., and Leonardi, G. R. (2018). Amine-modified hyaluronic acid-functionalized porous silicon nanoparticles for targeting breast cancer tumors. Opt. Nanomaterials 1-100 nm in size have special optical, magnetic, and electrical characteristics. In passive targeting, the drugs are successfully delivered to the target site in order to play a therapeutic role. VEGF in signaling and disease: beyond discovery and development. Advantages The top advantages of Nanotechnology are as follows: Durable Lightweight Stronger Cheaper Precise More efficient Devices are very small in size Faster Uses smaller batteries Hence, the applications of Nanotechnology are in a wide range of industries! doi: 10.1016/j.ejpb.2007.07.011, Cirillo, G., Vittorio, O., Kunhardt, D., Valli, E., Voli, F., Farfalla, A., et al. Keywords: doi: 10.1016/j.nano.2018.06.012, Xu, C., Lei, C., and Yu, C. (2019). doi: 10.1016/j.nano.2017.12.014, Low, P. S., and Kularatne, S. A. Chem. (2010). No use, distribution or reproduction is permitted which does not comply with these terms. 9, 19091915. Clipboard, Search History, and several other advanced features are temporarily unavailable. Overcoming STC2 mediated drug resistance through drug and gene co-delivery by PHB-PDMAEMA cationic polyester in liver cancer cells. Control Release 245, 4151. doi: 10.1038/scientificamerican0794-58, Jiang, Q., Liu, Y., Guo, R., Yao, X., Sung, S., Pang, Z., et al. AS and YD supervised the research and led the discussion. Oncol. Integrins in cancer: biological implications and therapeutic opportunities. doi: 10.1016/j.cell.2019.01.021, Bahrami, B., Hojjat-Farsangi, M., Mohammadi, H., Anvari, E., Ghalamfarsa, G., Yousefi, M., et al. Cancer nanotechnology is a branch of nanotechnology concerned with the application of both nanomaterials (such as nanoparticles for tumour imaging or drug delivery) and nanotechnology approaches . Cancer immunotherapy is mainly achieved by activating the anti-tumor immune response (Zang et al., 2017). J. Int. Nanotechnology-based diagnostics and therapeutics in acute lymphoblastic leukemia: a systematic review of preclinical studies. Protocols (2015). ACS Nano 12, 52415252. (2019). Adv. Sci. Different considerations of toxicology should be used when proposing that a given nanoparticle be used for a treatment of stage four cancer as compared to one to be used for a routine diagnostic medical imaging. Hypoxia is another factor that contributes to multidrug resistance (Jing et al., 2019). Therefore, active targeting is particularly suitable for macromolecular drug delivery, such as proteins and siRNAs. A single dose of carbon nanotubes enhances breast cancer metastasis in mouse models. doi: 10.1126/scitranslmed.3001385, Muralidharan, R., Babu, A., Amreddy, N., Basalingappa, K., Mehta, M., Chen, A., et al. Augmentation of therapeutic efficacy in drug-resistant tumor models using ceramide coadministration in temporal-controlled polymer-blend nanoparticle delivery systems. Specific targeting cancer cells with nanoparticles and drug delivery in cancer therapy. Am. Moreover, matrix metalloproteinase (MMP), a component of the tumor microenvironment, is engaged in extracellular matrix remodeling and tumor neovascularization (Lia et al., 2009). J. Nanomed. Trends Cancer 3, 529541. Drug Deliv. Current methods used for chemotherapy have various limitations, such as cytotoxicity, multi-drug resistance, stem-like cells growth, and lack of specificity. doi: 10.1002/adfm.201500594, Kundu, M., Sadhukhan, P., Ghosh, N., Chatterjee, S., Manna, P., Das, J., et al. Nature 407, 249257. Design, preparation and evaluation of different branched biotin modified liposomes for targeting breast cancer. During the process, hypoxia-inducible factor 1 (HIF-1) plays an essential role, and overexpression of HIF-1 has been observed in many human cancers (Vadde et al., 2017). doi: 10.1021/mp049970, Qin, L., Wu, L., Jiang, S., Yang, D., He, H., Zhang, F., et al. Technolog. doi: 10.1016/0006-2952(92)90443-m, Dadwal, A., Baldi, A., and Kumar Narang, R. (2018). 30:e1703740. 2014 Sep 30;76:79-97. doi: 10.1016/j.addr.2014.08.002. 27, 255264. Hence, increasingly more studies are seeking precise therapy of cancer and solutions for drug resistance. The NPs used in medical treatment usually have specific sizes, shapes, and surface characteristics as these three aspects have a major influence on the efficiency of the nano-drug delivery and thus control therapeutic efficacy (Bahrami et al., 2017). Biol. Due to their minute sizes, nanoparticles can enter the human body . Carcinogenesis 32, 667675. The research of nanotechnology in medicine is now focusing on areas like tissue regeneration, bone repair, immunity and even cures for such ailments like cancer, diabetes, and other life threatening diseases. Mesoporous silica nanoparticle carriers are a type of SNPs which are suitable for drug delivery (Almeida et al., 2014; Gao et al., 2019). This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). 2020;27(8):1367-1381. doi: 10.2174/0929867326666181220095343. (2005). In Asia, where there is a very positive perception of nanotechnology, some products have been marketed as being nano-enabled to justify charging a premium price. For example, targeting human epidermal receptor-2 (HER-2) is a common therapy for HER-2 positive breast and gastric cancer. Folic acid, a type of vitamin, is essential in nucleotide synthesis. Ficoll and dextran vs. globular proteins as probes for testing glomerular permselectivity: effects of molecular size, shape, charge, and deformability. Research Highlights Nanomed. 7:290. doi: 10.3389/fchem.2019.00290, Yang, Q., Jones, S. W., Parker, C. L., Zamboni, W. C., Bear, J. E., and Lai, S. K. (2014). (2020). Results indicated that the expression of anti-apoptotic genes was down-regulated, while the ABC-transporter markers were inhibited (Singh et al., 2018). Rezaianzadeh A, Jalali M, Maghsoudi A, Mokhtari AM, Azgomi SH, Dehghani SL. Although nanomedicine has shown benefits with respect to soluble drug administration, whether delivery of multiple drugs within the same nanocarrier has advantages over administration of single-drug nanomedicines or combination of free drugs at the same dosage is unclear. A 106, 32033210. Disclaimer. This strategy can be achieved by designing NPs that encapsulate both efflux pump inhibitors and chemotherapeutics (Soma et al., 2000), or by reducing the ATP that is supplied to the efflux pump (Wang et al., 2018c). 30:e1706759. (2017). doi: 10.1016/j.biomaterials.2018.10.019, Lia, N. G., Shib, Z. H., Tang, Y. P., and Duan, J. Theranostics 9, 33413364. Unable to load your collection due to an error, Unable to load your delegates due to an error. administration routes; metastatic mechanism; nanotechnology; ovarian cancer; treatment. Besides, hypoxia has also been proven to mediate the overexpression of drug efflux proteins (Xia et al., 2005). Cell 176, 12481264. eCollection 2023 Apr. doi: 10.1021/acsami.8b18717. (2008). Cancer Cell Membrane Decorated Silica Nanoparticle Loaded with miR495 and Doxorubicin to Overcome Drug Resistance for Effective Lung Cancer Therapy. 24 April 2020. 97, 733747. News & Views Khademi R, Mohammadi Z, Khademi R, Saghazadeh A, Rezaei N. Nanoscale Adv. Sci. Mater. doi: 10.1016/j.nano.2013.06.015, Perrault, S. D., Walkey, C., Jennings, T., Fischer, H. C., and Chan, W. C. (2009). Sci. | J. 56, 491509. 81, 128141. Reviews 02 March 2023, Research Would you like email updates of new search results? Large numbers of nano particles are safely injected into the body and preferentially bind to the cancer cell, defining the anatomical contour of the lesion and making it visible. Nanotechnol. Rev. Sin. 4:143. doi: 10.3389/fphar.2013.00143, Iwase, Y., and Maitani, Y. Some NPs do not directly target cancer cells but instead have an effect on angiogenesis, which is another method of cancer treatment. Doxorubicin loaded Polymeric Nanoparticulate Delivery System to overcome drug resistance in osteosarcoma. Recent Advances in Well-Designed Therapeutic Nanosystems for the Pancreatic Ductal Adenocarcinoma Treatment Dilemma. 2014 Jul-Aug;32(4):693-710. doi: 10.1016/j.biotechadv.2013.11.009. Tumor regression by targeted gene delivery to the neovasculature. Appl. J. Mater. (2020). Adv. Am. Potential nanotechnologies and molecular targets in the quest for efficient chemotherapy in ovarian cancer. See this image and copyright information in PMC. Visentin S, Sedi M, Paveli SK, Paveli K. Curr Med Chem. National Library of Medicine This chapter is devoted to the advances in the field of nanoparticles-mediated cancer treatment. Sci. The use of nanoparticle-mediated targeted gene silencing and drug delivery to overcome tumor drug resistance. (2017). Sothe 4 major advantages of CAR-T are: Using an autologous (patient-specific) cell decrease the risk of immunogenicity (host rejection) CAR-T will target only the tumor alone, so there's less adverse events that with a chemo/monoclonal antibody However, immunotherapy still faces many challenges in view of clinical efficacy and safety issues. Co-delivery of siRNA and an anticancer drug for treatment of multidrug-resistant cancer. A drug-delivering-drug strategy for combined treatment of metastatic breast cancer. 83, 210217. Recent advances with liposomes as pharmaceutical carriers. A., Petryk, J. D., Sechrist, S., Gladstone, D. J., et al. Rev. In vivo -catenin attenuation by the integrin 5-targeting nano-delivery strategy suppresses triple negative breast cancer stemness and metastasis. As p53 plays a significant role in apoptosis, reinstating p53 function or other tumor suppressors is considered a potential way to overcome drug resistance in cancer. Nanoscale Res. Bioconjug. Improving drug potency and efficacy by nanocarrier-mediated subcellular targeting. | Hepatology 67, 18721889. doi: 10.1016/j.canlet.2018.04.017, Soe, Z. C., Kwon, J. Drug Deliv. In recent years, nanoparticles (NPs) have repetitively been reported to play . Appl. 27:14. doi: 10.1002/adfm.201703303, Bertrand, N., Wu, J., Xu, X., Kamaly, N., and Farokhzad, O. C. (2014). Rev. HER-2-targeted nanoparticle-affibody bioconjugates for cancer therapy. Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance. doi: 10.1093/jnci/dji130, Eloy, J. O., Petrilli, R., Topan, J. F., Antonio, H. M. R., Barcellos, J. P. A., Chesca, D. L., et al. official website and that any information you provide is encrypted Commun. Pharm. Although nanovaccines and artificial APCs have demonstrated increased efficacy compared to traditional immunotherapy, the clinical efficacy of this treatment remains unsatisfactory, and the safety and tolerance of these new approaches need to be further investigated. Nanoprobe-mediated tracing of ovarian cancer metastases. News & Views Impact of nanotechnology on drug delivery. Their multiple functional groups on the surface enhance the capability of loading and delivering therapeutic agents. Control Release 148, 135146. Several studies have reported the effectiveness of nanosystems containing HIF-1 siRNA to overcome drug resistance in cancer (Zhao et al., 2015; Luan et al., 2018; Hajizadeh et al., 2020). Passive and active targeting of NPs to cancer cells. The https:// ensures that you are connecting to the Cells Nanomed. Cancer cell membrane-cloaked mesoporous silica nanoparticles with a pH-sensitive gatekeeper for cancer treatment. doi: 10.1016/j.msec.2019.01.066, Kamaly, N., Xiao, Z., Valencia, P. M., Radovic-Moreno, A. F., and Farokhzad, O. C. (2012). Additionally, hypoxia produces a gradient of oxygen within the tumor, thereby increasing tumor heterogeneity and promoting a more aggressive phenotype. COMSATS Institute of Information Technology, Pakistan. Nanoparticle (NP)-based drug delivery systems have shown many advantages in cancer treatment, such as good pharmacokinetics, precise targeting of tumor cells, reduction of side effects, and drug resistance ( Dadwal et al., 2018; Palazzolo et al., 2018 ). doi: 10.1016/j.coi.2013.03.001, Pelicano, H., Martin, D. S., Xu, R. H., and Huang, P. (2006). They are versatile and biocompatible macromolecules that are characterized by a three-dimensional branch structure (Nanjwade et al., 2009; Sherje et al., 2018). (2015). Passive targeting of NPs is mainly achieved by the enhanced permeability and retention (EPR) effect, which exploits the increased vascular permeability and weakened lymphatic drainage of cancer cells and enables NPs to target cancer cells passively. Cancer biomarker; Cancer diagnosis; Nanoparticle. EJC Suppl. doi: 10.1016/j.jconrel.2019.01.009, Murakami, M., Cabral, H., Matsumoto, Y., Wu, S., Kano, M. R., Yamori, T., et al. 4), S9S15. 271, 5865. Functionalized gold nanoparticles for drug delivery. the reclamation potential and toxicity reduction. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Co-Delivery of Curcumin and Paclitaxel by Core-Shell targeting amphiphilic copolymer to reverse resistance in the treatment of ovarian cancer. Nanoscale Res. Moreover, developing immunomodulatory factor-loaded NPs may improve the effectiveness of vaccines for immunotherapy. the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in In addition to directly inhibiting the function of HIF-1, indirect inhibition of HIF-1 signaling has also been previously considered. doi: 10.1016/j.ijpharm.2018.07.030, Shi, J., Xiao, Z., Kamaly, N., and Farokhzad, O. C. (2011). Please enable it to take advantage of the complete set of features! doi: 10.1016/j.addr.2014.05.009, Chen, Y., Zhu, X., Zhang, X., Liu, B., and Huang, L. (2010). doi: 10.1021/ar200054n, Siegel, R. L., Miller, K. D., and Jemal, A. 4, 145160. Mol. Nanotechnology has the potential to bring major advances in medicine. 17AAG, 17-allylamino-17-demethoxygeldanamycin; ABC, ATP binding cassette; ADCC, antibody dependent cell cytotoxicity; APC, antigen-presenting cell; AuNPs, gold nanoparticles; Bcl-2, B cell lymphoma-2; CNT, carbon nanotubes; COX-2, cyclooxygenase 2; DC, dendritic cell; DTXL, docetaxel; EGFR, epidermal growth factor receptor; EPR, enhanced permeability and retention; FR- , alpha isoform of folate receptor; GM-CSF, granulocyte-macrophage colony-stimulating factor; HER-2, human epidermal receptor-2; HIF-1 , hypoxia-inducible factor 1 ; HSP90, heat shock protein 90; IFN- , interferon ; KDR, kinase-insert domain-containing receptor; LSH, liposome-silica hybrid; MDCS, myeloid derived suppressor cell; MDR, multidrug resistance; MMP, matrix metalloproteinase; MNPs, magnetic nanoparticles; MOMP, mitochondrial outer membrane permeabilization; mTOR, mammalian target of rapamycin; NF- B, nuclear factor kappa B; NPs, nanoparticles; PDTC, pyrrolidine dithiocarbamate; PEG, polyethylene glycol; P-gp, P-glycoprotein; PI3K, phosphoinositol-3-kinase; PLGA, polylactic-co-glycolic acid; SNP, silica nanoparticles; TAA, tumor-associated antigen; TAM, tumor-associated macrophage; TCR, T cell receptor; TME, tumor microenvironment; Tregs, regulatory T cells; VCAM-1, vascular cell adhesion molecule-1; VEGF, vascular endothelial growth factor; VEGFRs, VEGF receptors. 137, 115170. official website and that any information you provide is encrypted The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. 2020 Apr 10;320:105-111. doi: 10.1016/j.jconrel.2020.01.041. , Low, P. S., Gladstone, D. J., Xiao, Z. C., and deformability a role! Strategy for combined treatment of metastatic breast cancer metastasis in mouse models supervised! The Pancreatic Ductal Adenocarcinoma treatment Dilemma and non-pump-mediated drug resistance regression by targeted gene delivery to the in! A series of nanogels with distinctive stiffness and investigate how nanogel mechanical properties could be leveraged to drug... Overcome both pump- and non-pump-mediated drug resistance in osteosarcoma nanoparticles ( NPs ) have repetitively been reported to a! Can enter the human body in temporal-controlled polymer-blend nanoparticle delivery systems, Xiao, Z. Kamaly. Xu, C. ( 2019 ) ; 32 ( 4 ):515-538. doi: 10.1016/j.ijpharm.2018.07.030 Shi. Treatment of ovarian cancer efficacy by nanocarrier-mediated subcellular targeting mediate the overexpression of drug efflux (! Like email updates of new Search results: 10.1016/j.nano.2017.12.014, Low, P. S., and Kularatne S.... 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