Eur J Radiol Open. [PDF], Nanotheranostics 2023; 7(3): 281-298. 2 /5. Imaging 47, 934946 (2020). Theelen, W. S. M. E. et al. Finally, the cover letter should provide any additional information that may be helpful to the editor. (2022). 2021;385(12):1091-103. A randomized study comparing yttrium-90 ibritumomab tiuxetan (Zevalin) and high-dose BEAM chemotherapy versus BEAM alone as the conditioning regimen before autologous stem cell transplantation in patients with aggressive lymphoma. J. Clin. Google Scholar. J. Nucl. Proc. And the use of animals in experiments will have observed the Interdisciplinary Principles and Guidelines for the Use of Animals in Research, Testing, and Education by the New York Academy of Sciences, Ad Hoc Animal Research Committee. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Do not capitalize abbreviation definitions. Please enable it to take advantage of the complete set of features! J. Nucl. 55, 534539 (2014). Parker, C. et al. Immunogenic priming with 177Lu-PSMA-617 plus pembrolizumab in metastatic castration resistant prostate cancer (mCRPC): a phase 1b study. Sgouros, G., Bodei, L., McDevitt, M. R. & Nedrow, J. R. Radiopharmaceutical therapy in cancer: clinical advances and challenges. Schoenfeld, J. D. et al. Typically injected into the patient's bloodstream, the therapy radiopharmaceuticals travel and deliver . . The emphasis on seeing is a key part of what distinguishes theranostics from other forms of precision medicine, and even chemotherapy. Seidlin, S. M., Marinelli, L. D. & Oshry, E. Radioactive iodine therapy; effect on functioning metastases of adenocarcinoma of the thyroid. Who can you collaborate with on writing the proposed review? If possible, the figures should be submitted as the size they will appear when published so that no reduction is necessary. Please be aware that an author's use of language editing services in no way guarantees that his or her submission will ultimately be accepted. Use Symbol fonts for ""; "" and "" (avoid underlining characters). Lancet Oncol. [Abstract] 54, 13891396 (2013). & Kjaer, A. Synergistic effect of combined treatment with 177Lu-DOTATATE and Everolimus in neuroendocrine tumors as monitored by 18F-FDG-PET: studies in human neuroendocrine xenografts [abstract]. Market Research Report. Front Med (Lausanne). J. Nucl. Present abbreviations alphabetically in one paragraph, in the format: "term: definition". 376, 125135 (2017). Cancer 1, 47064714 (2012). The field of radiotheranostics, which is the focus of this Review, combines molecular imaging (primarily PET and SPECT) with targeted radionuclide therapy, which involves the use of small molecules, peptides and/or antibodies as carriers for therapeutic radionuclides, typically those emitting -, - or auger-radiation. Cheung TMT, Capozza M, Cotugno S, Tafuri S, Bianchi FP, Schettini F, et al. Currency Converter (external source). Price changes and within-class competition of cancer drugs in the USA and Europe: a comparative analysis. This work was supported in part by NIH grants R35 CA232130 (J.S.L.) Automate citations and referencing with our tool, Citationsy. Physical treatment in psychiatry. B. News-Medical. 41, 459 (2021). Cancer misinformation and harmful information on facebook and other social media: a brief report. Arthroplasty in the hand and wrist. 2000;11(8):33. Lindner, T. et al. Please use plain text in references, no image or math equation. Shi M, Jakobsson V, Greifenstein L, Khong PL, Chen X, Baum RP, Zhang J. This is in addition to their better bioavailability and augmented tumor delivery. Check for errors and try again. One of the biggest areas in theranostics is nuclear medicine. 20, 3843 (1993). Radioactive iodine, for example, has been used for decades to both diagnose and treat thyroid cancer. Examples include advanced MR acquisition techniques, motion correction, MR fingerprinting, artificial intelligence, and deep . De la Vieja, A. Lutetium-177PSMA-617 for Metastatic Castration-Resistant Prostate Cancer. Friedberg, J. W. & Fisher, R. I. Iodine-131 tositumomab (Bexxar): radioimmunoconjugate therapy for indolent and transformed B-cell non-Hodgkins lymphoma. has acted as an adviser of Boxer, Clarity Pharmaceuticals, Curie Therapeutics, Earli, Evergreen Theragnostics, Telix Pharmaceuticals, TPG Capital and Varian Medical Systems; is a co-inventor on technologies licensed to Diaprost, Daiichi Sankyo, Elucida Oncology, Macrocyclics and Samus Therapeutics; and is the co-founder of, and holds equity in, pHLIP and Sharp RTx. Joint EANM, SNMMI and IAEA enabling guide: how to set up a theranostics centre. Eur. 2023 Jan 31;10:100477. doi: 10.1016/j.ejro.2023.100477. Johnson, S. B. et al. The ultimate aim of combining nanomedicine and theranostics is to modify disease and patient-specific outcomes in such a way that they are drastically improved. Med. Br. Retrieved on March 18, 2023 from https://www.news-medical.net/health/What-is-Theranostics.aspx. Provide illustrative examples of a spectrum of radiopharmaceuticals in precision oncology. - Authors reply. Theranostics is an emerging paradigm that combines imaging and therapy in order to personalize patient treatment. Ballal, S., Yadav, M. P., Bal, C., Sahoo, R. K. & Tripathi, M. Broadening horizons with (225)Ac-DOTATATE targeted alpha therapy for gastroenteropancreatic neuroendocrine tumour patients stable or refractory to (177)Lu-DOTATATE PRRT: first clinical experience on the efficacy and safety. In addition . Theranostics: one stone can kill two or three birds. Rajkumar, S. V. The high cost of insulin in the United States: an urgent call to action. L.B. The ability to acquire a diagnosis and administer therapy in one package is a game-changer for medicine as we know it. PubMed 2002; 347: 2010-9. Med. 21, 561570 (2020). Hepatol. This ensures that the drug bypasses tissues that are off-target, and in doing so improves the therapeutic index. Medical imaging and nuclear medicine: a Lancet Oncology Commission. Med. Assoc. Theranostics is a term derived from a combination of the words therapeutics and diagnostics. However, in theory any cytotoxic drug could be used. ADVERTISEMENT: Supporters see fewer/no ads. An urgent call to raise the bar in oncology. A.M.S. 5. PubMedGoogle Scholar. Conflict of interests (also called "competing interest") that might interfere with the objective presentation of the research J. Nucl. Radiation therapy enhances immunotherapy response in microsatellite stable colorectal and pancreatic adenocarcinoma in a phase II trial. Endocr. Please avoid using math equations in Microsoft Word whenever possible, as they have to be replaced by images in xml full text. Before Based on responses to internal or external stimuli, these nanoparticles are capable of administering exact concentrations of the required therapeutic agents. Combination strategies to improve targeted radionuclide therapy. Johns Hopkins is a leader in the development and use of theranostics. The maximum file size for supplementary materials is 10MB each un-compressed. 2, 12 (2015). Authors should pay careful attention to the required reference formatting and manuscript sections. Additional holmium-166 radioembolisation after lutetium-177-dotatate in patients with neuroendocrine tumour liver metastases (HEPAR PLuS): a single-centre, single-arm, open-label, phase 2 study. 4. USA 10, 2831628327 (2020). including the name of the board/committee that gave the approval. N. Engl. News-Medical.Net provides this medical information service in accordance Shah HJ, Ruppell E, Bokhari R, Aland P, Lele VR, Ge C, McIntosh LJ. Please strictly follow the format. Mol. N Engl J Med. Addition of two important facets . 2022 Nov 23;23(23):14590. doi: 10.3390/ijms232314590. J. Nucl. Carefully drawn figures that serve to illustrate the theme of the paper are desired. To which communities will your article appeal? For human studies, approval must be obtained from the institutional review board or equivalent ethics committee and written informed consent must be obtained from research subjects, unless this requirement is waived by the institutional review board or equivalent. 22, e136e172 (2021). Jason S. Lewis. Use "/" for "divide" or "over", e.g., 1/7, 5/(4+6). The cover letter should inform the editor of potential overlap with other material already published or submitted for publication and should provide a reference to or a copy of this material. the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Congressional Budget Office. [Author surname] [Author initials], [Other author surnames & initials]. 60, 16631664 (2019). Med. 177Lu-Dotatate plus long-acting octreotide versus highdose long-acting octreotide in patients with midgut neuroendocrine tumours (NETTER-1): final overall survival and long-term safety results from an open-label, randomised, controlled, phase 3 trial. National Library of Medicine Semin. Pivotal study of iodine I 131 tositumomab for chemotherapy-refractory low-grade or transformed low-grade B-cell non-Hodgkins lymphomas. Strosberg J, El-Haddad G, Wolin E et al. Urol. In nuclear medicine, the term theranostics describes the combination of therapy and diagnostic imaging. Pozen, A. Radiopharmaceuticals Market By Radioisotope Type (Technetium-99, Fluorine-18, Iodine-131, Leutetium-177), Application (Oncology, Cardiology, Gastroenterology, Neuroendocrinology, Neurology, Nephrology), Source (Cyclotrons, Nuclear Reactors) & Region Forecast 20212031. Article Role of metabolism in cancer cell radioresistance and radiosensitization methods. 20, 408419 (2019). Med. Med. According to theInternational Committee of Medical Journal Editors: Financial relationships (such as employment, consultancies, stock ownership or options, honoraria, patents, and paid expert testimony) are the most easily identifiable, the ones most often judged to represent potential conflicts of interest and thus the most likely to undermine the credibility of the journal, the authors, and of science itself. Cancer 12, 278287 (2012). In: [Editor surname] [Editor initials], Ed. 369, 213223 (2013). Graphical abstract will be published online in the table of content. Yordanova, A. et al. has received personal fees from Adacap, Aktis Oncology, Amgen, Bayer, BTG, Curium, Endocyte, GE Healthcare, IPSEN, Pharma15, Novartis, Siemens Healthineers, SIRTEX, Theragnostics and YMabs; has received non-financial support from ABX and Sofie Biosciences and has received research funding from BTG. Med. The aim is to visualise potential biological targets and develop a personalised . It is annoying if readers cannot find the web pages when clicking on the links. For studies in the United States, compliance with the Health Insurance Portability and Accountability Act is also required. A note on plagiarism: There is a zero-tolerance policy towards plagiarism (including self-plagiarism) in our journals. One of the classic examples of theranostics is the use of Ga-68 labeled tracers, wherein the diagnosis using this generator-derived radionuclide can be effectively followed by the therapy using therapeutic radionuclides like Lu-177 and Y-90 labeled with the same tracer for personalized radionuclide therapy. Chem. Funkhouser, J. Rev. J. Natl Cancer Inst. Submitted manuscripts are reviewed for originality, significance, adequacy of documentation, composition, and adherence to these guidelines. Nat. . 1. and JavaScript. in the journal abbreviations. If a significant amount of other people's material is to be used, either textual or image-based, permission must be sought by the author in accordance with copyright law and must be made clear in the manuscript. 16, 15741581 (1998). Theranostics is a personalised approach to treating cancer, using similar molecules for both imaging (diagnosis) and therapy. Pronunciation of theranostics with 1 audio pronunciations. Please usethe NLM Catalog (https://www.ncbi.nlm.nih.gov/nlmcatalog/journals) to find the abbreviations of journals. 383, 640649 (2020). Current Drug Discovery. Aggarwal, R. S. et al. Open Access One of the oldest examples of this is the use of radioactive iodine for treatments and imaging of thyroid cancer in the 1940s. 8, 692436 (2021). Legends: Include a legend below each figure. ISSN 1759-4782 (online) Addition of radium-223 to abiraterone acetate and prednisone or prednisolone in patients with castration-resistant prostate cancer and bone metastases (ERA 223): a randomised, double-blind, placebo-controlled, phase 3 trial. UC Davis Health is planning a new clinic dedicated to the innovative treatment. This section will summarize noteworthy examples of theranostics responsive to pH, focusing on the mentioned classes of materials. 2. 1. Potentiation of peptide receptor radionuclide therapy by the PARP inhibitor olaparib. Markham, M. J. et al. Google Scholar. Doctors use a pair of radiotracers that are virtually identical, other than the type of radiation they give off. Lancet Gastroenterol. 32, 123132 (2002). ISSN 1759-4774 (print). Molecules 26, 3966 (2021). To obtain Timmerman, L. Why Good Drugs Sometimes Fail: The Bexxar Story, https://xconomy.com/national/2013/08/26/why-good-drugs-sometimes-fail-in-the-market-the-bexxar-story/ (2013). This revolutionary technique represents an evolving form of cancer care that may improve patients' experiences and treatment outcomes. 95, 2228 (2020). 6, 162 (2021). Integrin v3-targeted radionuclide therapy combined with immune checkpoint blockade immunotherapy synergistically enhances anti-tumor efficacy. CAS These studies investigate the use of nanomedicines in an active or passive manner to trigger site-specific release of drugs. Practice Requirements for Patient-Specific Care: Examples from Theranostics and MR of Implanted Devices Starting a Medical Physics Business A Camp Survival Story: Adaptation of Private Practice Medical Physics Over Time Industry Perspective on a Successful Medical Physics Business G White, R Fisher, H Edmonson, R Staton, K Lofton J. Clin. J. Nucl. Front. Proc. 5, 856863 (2019). Urol. de Keizer, B. et al. Apr 3, 2018. Valkenburg, K. C., De Groot, A. E. & Pienta, K. J. Mol. Reinventing pharma: The theranostic revolution. J. Nucl. Efficacy and safety of high-specific-activity 131I-MIBG therapy in patients with advanced pheochromocytoma or paraganglioma. Hricak, H. et al. Experimental research In the EndNote tab, select Style: ivyspring. In line with the preceding statement, nanoparticles are able to target diseased areas within the body, thereby avoiding damage to healthy tissues. Revised 26 September 2003. https://www.who.int/ Manuscripts should adhere to the journal style detailed in this guideline to expedite the publishing process. PubMed Central Samnick, S. et al. Signal. J. Haematol. Radiotheranostics in oncology: current challenges and emerging opportunities. on this website is designed to support, not to replace the relationship Theranostics enables us to combine a fast and accurate cancer diagnosis with precisely targeted therapy. 53, 57 (2012). Early studies, for example, have suggested an . Communications Chemistry Parikh, A. R. et al. In the main text or figure/table legends, please do not color the fonts or use smaller font size to distinguish one text from other texts. Write subtitles and headings in sentence case. Eur. Epub 2009 Aug 28. Batra, J. S. et al. For example, theranostics may allow for evaluation of the "enhanced permeability retention" phenomenon functionality and heterogeneity in solid tumors for patient selection. Suthiram J, Pieters A, Mohamed Moosa Z, Zeevaart JR, Sathekge MM, Ebenhan T, Anderson RC, Newton CL. with these terms and conditions. Ann. CAS Anticancer. Satapathy, S. et al. Radiopharm. Genolla, J. et al. All published articles of our journal are permanently archived by PubMed Central of US National Library of Medicine and Europe PMC. Rate the pronunciation difficulty of theranostics. Cancer Biother. 32, S626S677 (2021). Med. To insert a symbol use Insert/Symbol/ in the Microsoft Word menu. Mol. 181, 490498 (2021). Med. & Cutler, D. M. Medical spending differences in the United States and Canada: the role of prices, procedures, and administrative expenses. 1, 60 (2020). Kwekkeboom DJ, Krenning EP, Lebtahi R, Komminoth P, Kos-Kuda B, de Herder WW, Plckinger U; Mallorca Consensus Conference participants; European Neuroendocrine Tumor Society. Michael Burcham. 5. Mol. Article Med. Supplementary materials appear online linked to the paper and are not edited. Oncol. Abstract. Phallen, J. et al. List of nationally authorised medicinal products, https://www.ema.europa.eu/en/documents/psusa/iodine-131i-iobenguane-list-nationally-authorised-medicinal-products-psusa/00001764/201505_en.pdf (2016). Authors are responsible for ensuring all supplementary material meets the scientific and style standards of the main text and figures. For example, "mg/mL" and "mM" are acceptable non-SI units for concentration. This method combines the therapeutic use of radio pharmaceuticals and is known as Theranostics. Then open MS Word. 14, 365379 (2017). involving human or animals should have been approved by author's institutional Med. Pavlakis, N. et al. Eur. J. Nucl. Kratochwil, C. et al. J. Endocrinol. 2023 Ivyspring International Publisher. Theranostics has been in medical use in other clinical care areas long before its use in prostate cancer. Oncol. J. Emerging as a specific, safe, and efficient molecular-targeted discipline, theranostics focuses on patient-centered care. Compilation of the top interviews, articles, and news in the last year. & Turner, J. H. Phase II study of radiopeptide 177Lu-octreotate and capecitabine therapy of progressive disseminated neuroendocrine tumours. Mottet N., et al. Eur. Ther. This site complies with the HONcode standard for trustworthy health information: verify here. EAU Guidelines: Prostate Cancer, https://uroweb.org/guideline/prostate-cancer/ (2001). With theranostics, it's very different. Authors whose first language is not English are encouraged to ask a colleague to proofread the manuscript before submission. 1, 884885 (2021). 50, 20252032 (2009). 9, 467475 (2021). 1. Please put the style file in Windows C:\Program Files (x86)\EndNote X?\Styles ('?' Theranostics accepts original scientific and review articles. Weber, M. et al. Competing interests that might interfere with the objective presentation of the research findings contained in the manuscript must be declared. We particularly encourage international and multidisciplinary collaborations among our authors. The Division of Nuclear Medicine and Molecular Imaging has pioneered the development of imaging and theranostic agents for prostate cancer. You are using a browser version with limited support for CSS. 28, 606608 (2022). Payment can be made by credit card (Visa/MasterCard/UnionPay) or bank transfer. Theranostics 9, 79487960 (2019). Baum, R. P. et al. Kratochwil, C., Haberkorn, U. Scott, A. M., Wolchok, J. D. & Old, L. J. Circulating androgen receptor gene amplification and resistance to 177Lu-PSMA-617 in metastatic castration-resistant prostate cancer: results of a phase 2 trial. Theranostics, 11 (2021), pp. Eur. All authors made an equal contribution to all aspects of the preparation and writing of this manuscript. Wilson, Damien Jonas. Further examples can include heat-activated drug delivery, targeted drug delivery, tissue-selective drug delivery, using vascular targeting agents, using a carrier or selective permeation of the anticancer agent into the tumour, among others. volume19,pages 534550 (2022)Cite this article. Radioiodine, which is taken up by the thyroid gland, thus allowing metastases to be visualized in a scan. Lancet Gastroenterol. PubMed Central For articles with six or more authors, use "et al.". Our journal is fully open-access with articles freely available in the journal website including PDF, xml, and supplementary materials if applicable. & Reilly, R. M. Auger electrons for cancer therapy - a review. NCCN. J. Nucl. Med. Mol. A good review should also be a timely account that is needed and adds genuinely to the existing literature. At GenesisCare, we offer Theranostics treatments for metastatic prostate cancer (177Lutetium PSMA therapy and Radium-223 . Samarium-153-Lexidronam complex for treatment of painful bone metastases in hormone-refractory prostate cancer. Natl Acad. Once the area of interest has been pinpointed, nanoparticles may then provide information on the extent of the disease, and even indicate disease response to treatment, if applicable. Except for the rationale, these sections should be preceded by headings (i.e., Methods, Results, and Conclusion). theragnostics 6) uses a diagnostic examination to determine if a patient may benefit from a specific therapeutic drug and thus couples the therapy with diagnostic information specific for the intended target 2.. Theranostics promises improved patient selection for therapy on the basis of specific molecular features of disease, using information from pharmacogenetics . Theranostics, which is in essence a portmanteau of therapy and diagnostic, has . Oncol. Difficult. -. Lancet Oncol. To zip files in Windows, select the files and right click "Send to > Compressed (zipped) folder". Dive in to discover how Bruker will rise to the challenge. https://www.datamintelligence.com/research-report/theranostics-market (2021). Furthermore, they can play an additional role in the monitoring of the drug delivery, release and efficacy. Federal government websites often end in .gov or .mil. Eur. Ichikawa Y, Kobayashi N, Takano S, Kato I, Endo K, Inoue T. Cancer Sci. Submissions by email of any manuscript files, either to the editors or to the journal office, are not acceptable and are discarded automatically. Abbreviations used in each figure should be defined in the legend in alphabetical order. Mol. Article All review content should consist of original text and interpretation, avoiding any direct reproduction. 50, 133140 (2020). Emmett, L. et al. Lancet Oncol. The graphical abstract should be colored, and kept within an area of 12 cm (width) x 6 cm (height). 59, 14151422 (2018). J. Clin. Contrast agents in theranostics: some examples and perspectives Biomarker approach. NCCN. Bodei, L. et al. Eur. Important: please write the first name and middle name before the surname, e.g., "Mike Johnson" (not "Johnson, Mike"; not "Johnson M."; not "M. Johnson"). Many articles state that the term theranostic was coined in 2002 by John Funkhouser 1; however it is clear from a simple Pubmed search that an article from 2000 employs this term with a similar meaning 9. The use of molecules to safely transport radioactive materials inside the human body helps doctors to obtain more precise images of the tumors and thus eliminate cancerous cells more effectively.